Movement Disorder Evaluation

Important

This report is intended to assist qualified Health Care Profesionals (HCP) in the assessment of an individual referred under the suspicion of having Parkinson’s Disease.

Clinical Context

This report presents several AI metrics derived from objective measures from individuals performing a battery of test using Manus Neurodynamica NeuroMotor PenTM.

These presented metrics combine factors from detailed measurement recordings made whilst the individual performs a battery of well established neurological test tasks.

The metrics have been assessed in a UK reference population and an individual’s results are presented in this clinical context. The HCP should review Clinical,Reference, Study et al [1] to establish applicability and limitations.

The information in this report should be used in the context of a full neurological assessment conducted to the current standard of care practices to establish a diagnosis.

Subject and Recording Details

Subject ID NMC011
Sex MALE
Dominant hand LEFT
Test date and time 2022-02-24 16:51
Test battery Circle, Spiral, Elel, FITTS Short Modified, FITTS Long Modified, ZigZag, ZigZag Offset
Operator comment madopar a 250 mg 4x1/4

Overall Assessment

PD

Subject performance similar to PD population (recommend review of report details)

Clinical context

In the clinical reference population, 19 individuals with a value less than 0.57 were subsequently diagnosed with PD. That is, 45.24% of the PD diagnoses in the study.

Additionally, 0 individuals with a value greater or equal to 0.57 were subsequently diagnosed as non PD. That is, 0.0% of the non PD diagnoses in the study.

Symptom Scores

These mini boxplots show the scores in a clinical context. Currently against the ‘Walker study’ data. A bigger pool would be much better (so max 83 individuals, usually lower if raw data did not result in successful classification).

The scores are ‘relative to the PD cohort’ and this is how they should be interpreted. A consequence of this is that a low tremor score below may actually correspond to obvious tremor in the raw data, and vice versa.

Micrographia

The micrographia symptom assessment is derived from a combination of factors in the elel task.

{'FN': 34, 'TN': 25, 'TP': 8, 'FP': 5}

Tremor

The tremor score is a combination of features in the circle, spiral and both zizag tasks.

{'FN': 27, 'TN': 26, 'TP': 15, 'FP': 4}

Bradykinesia

The bradykinesia score is a combination of features in the circle, spiral, both zizag and elel tasks.

{'FN': 20, 'TN': 10, 'TP': 22, 'FP': 20}

Spatial Accuracy

The accuracy score is a combination of factors in the spiral, both zigzags and both Fitts tasks.

{'FN': 24, 'TN': 17, 'TP': 18, 'FP': 13}

Test Battery Details

Circle

numCircles 10
timePerCircleMean 10.52
timePerCircleCoV 0.36321
timePerCircleSlope -0.0841111
meanError 1.83663
tremorFreq 6.73828
tremorRelPower 32.6892
tremorGyroAmpMean 0.0211955
tremorGyroAmpSlope -0.00867513
tremorGyroAmpCoV 0.361326
tremorCoordAmpMean 0.0489296
tremorCoordAmpSlope -0.00246533
tremorCoordAmpCoV 0.357508
tremorAccAmpMean 0.0316312
tremorAccAmpSlope -0.00709503
tremorAccAmpCoV 0.32655
tremorPcRelVar 0.663459
tremorPcX -0.326538
tremorPcY -0.945184

Circle Segment 1

Duration 17.28 s, Accuracy Estimate 2.819 (lower is better)

Circle Segment 2

Duration 18.16 s, Accuracy Estimate 1.573 (lower is better)

Circle Segment 3

Duration 8.0 s, Accuracy Estimate 1.485 (lower is better)

Circle Segment 4

Duration 9.12 s, Accuracy Estimate 1.503 (lower is better)

Circle Segment 5

Duration 9.2 s, Accuracy Estimate 1.656 (lower is better)

Circle Segment 6

Duration 9.2 s, Accuracy Estimate 1.508 (lower is better)

Circle Segment 7

Duration 8.64 s, Accuracy Estimate 1.512 (lower is better)

Circle Segment 8

Duration 8.84 s, Accuracy Estimate 1.883 (lower is better)

Circle Segment 9

Duration 8.48 s, Accuracy Estimate 1.959 (lower is better)

Circle Segment 10

Duration 8.28 s, Accuracy Estimate 2.468 (lower is better)

Spiral

numSpirals 10
timePerSpiralMean 25.024
timePerSpiralCoV 0.0872989
timePerSpiralSlope -0.0040107
meanError 1.83972
tremorFreq 6.44531
tremorRelPower 24.8748
tremorGyroAmpMean 0.0266028
tremorGyroAmpSlope 0.000204051
tremorGyroAmpCoV 0.339409
tremorCoordAmpMean 0.0456903
tremorCoordAmpSlope -0.000127708
tremorCoordAmpCoV 0.305898
tremorAccAmpMean 0.0418997
tremorAccAmpSlope 0.000398351
tremorAccAmpCoV 0.347364
tremorPcRelVar 0.696023
tremorPcX -0.186142
tremorPcY -0.982523

Spiral Segment 1

Duration 28.52 s, Accuracy Estimate 1.636 (lower is better)

Spiral Segment 2

Duration 23.0 s, Accuracy Estimate 1.946 (lower is better)

Spiral Segment 3

Duration 27.2 s, Accuracy Estimate 1.561 (lower is better)

Spiral Segment 4

Duration 23.64 s, Accuracy Estimate 2.068 (lower is better)

Spiral Segment 5

Duration 22.96 s, Accuracy Estimate 2.18 (lower is better)

Spiral Segment 6

Duration 24.68 s, Accuracy Estimate 1.905 (lower is better)

Spiral Segment 7

Duration 25.96 s, Accuracy Estimate 1.658 (lower is better)

Spiral Segment 8

Duration 21.68 s, Accuracy Estimate 1.835 (lower is better)

Spiral Segment 9

Duration 26.68 s, Accuracy Estimate 1.935 (lower is better)

Spiral Segment 10

Duration 25.92 s, Accuracy Estimate 1.674 (lower is better)

Elel

eDurationMean 0.497197
eDurationStd 0.13568
eDurationStdnorm 0.272889
eDurationMedian 0.475017
eDurationQuartdelta 0.0775028
eDurationQuartdeltanorm 0.163158
eDurationKurt 10.5108
eDurationTrenddiff -0.0300011
eDurationTrendratio 0.938144
eWidthMean 2.10848
eWidthStd 1.07896
eWidthStdnorm 0.511723
eWidthMedian 1.872
eWidthQuartdelta 1.37384
eWidthQuartdeltanorm 0.733887
eWidthKurt 7.50391
eWidthTrenddiff -0.351
eWidthTrendratio 0.823529
eHeightMean 8.83753
eHeightStd 2.90826
eHeightStdnorm 0.32908
eHeightMedian 8.424
eHeightQuartdelta 2.66175
eHeightQuartdeltanorm 0.315972
eHeightKurt 5.41588
eHeightTrenddiff -0.234
eHeightTrendratio 0.972222
eAspectMean 0.233523
eAspectStd 0.0701048
eAspectStdnorm 0.300205
eAspectMedian 0.228571
eAspectQuartdelta 0.0986085
eAspectQuartdeltanorm 0.431412
eAspectKurt 6.39449
eAspectTrenddiff -0.0697897
eAspectTrendratio 0.733904
eSlantMean -0.130196
eSlantStd 0.117789
eSlantStdnorm -0.904704
eSlantMedian -0.137114
eSlantQuartdelta 0.143653
eSlantQuartdeltanorm -1.04769
eSlantKurt 2.41322
eSlantTrenddiff -0.0595234
eRtopMean 0.715558
eRtopStd 0.188733
eRtopStdnorm 0.263756
eRtopMedian 0.777778
eRtopQuartdelta 0.208859
eRtopQuartdeltanorm 0.268533
eRtopKurt 3.09762
eRtopTrenddiff -0.0681471
eRbotMean 1.35283
eRbotStd 0.53971
eRbotStdnorm 0.398948
eRbotMedian 1.39188
eRbotQuartdelta 0.931931
eRbotQuartdeltanorm 0.669549
eRbotKurt 2.51787
eRbotTrenddiff 0.397937
eRrightMean 0.891607
eRrightStd 0.119812
eRrightStdnorm 0.134377
eRrightMedian 0.917424
eRrightQuartdelta 0.0777762
eRrightQuartdeltanorm 0.0847768
eRrightKurt 21.653
eRrightTrenddiff 0.00433735
eRleftMean 0.531313
eRleftStd 0.161708
eRleftStdnorm 0.304355
eRleftMedian 0.513707
eRleftQuartdelta 0.232786
eRleftQuartdeltanorm 0.45315
eRleftKurt 2.49234
eRleftTrenddiff 0.161057
lDurationMean 0.65044
lDurationStd 0.135838
lDurationStdnorm 0.20884
lDurationMedian 0.637523
lDurationQuartdelta 0.195007
lDurationQuartdeltanorm 0.305882
lDurationKurt 2.63831
lDurationTrenddiff -0.0675024
lDurationTrendratio 0.90146
lWidthMean 3.2343
lWidthStd 1.58875
lWidthStdnorm 0.491218
lWidthMedian 2.691
lWidthQuartdelta 1.52154
lWidthQuartdeltanorm 0.565418
lWidthKurt 6.06692
lWidthTrenddiff -1.1115
lWidthTrendratio 0.698413
lHeightMean 19.3085
lHeightStd 5.06529
lHeightStdnorm 0.262336
lHeightMedian 17.3886
lHeightQuartdelta 4.12392
lHeightQuartdeltanorm 0.237162
lHeightKurt 4.62995
lHeightTrenddiff -2.03177
lHeightTrendratio 0.894104
lAspectMean 0.162244
lAspectStd 0.0411404
lAspectStdnorm 0.253571
lAspectMedian 0.160815
lAspectQuartdelta 0.0569528
lAspectQuartdeltanorm 0.354151
lAspectKurt 2.72175
lAspectTrenddiff -0.0222318
lAspectTrendratio 0.872079
lSlantMean -0.0464594
lSlantStd 0.087218
lSlantStdnorm -1.8773
lSlantMedian -0.046907
lSlantQuartdelta 0.108337
lSlantQuartdeltanorm -2.30961
lSlantKurt 3.45753
lSlantTrenddiff -0.0554612
lRtopMean 0.808989
lRtopStd 0.127568
lRtopStdnorm 0.157688
lRtopMedian 0.833333
lRtopQuartdelta 0.143106
lRtopQuartdeltanorm 0.171727
lRtopKurt 4.94683
lRtopTrenddiff 0.00477954
lRbotMean 1.18657
lRbotStd 0.510493
lRbotStdnorm 0.430224
lRbotMedian 1.09348
lRbotQuartdelta 0.731947
lRbotQuartdeltanorm 0.669375
lRbotKurt 2.39781
lRbotTrenddiff 0.381476
lRrightMean 0.928432
lRrightStd 0.0566441
lRrightStdnorm 0.0610106
lRrightMedian 0.935606
lRrightQuartdelta 0.0592799
lRrightQuartdeltanorm 0.0633599
lRrightKurt 5.86062
lRrightTrenddiff 0.0319689
lRleftMean 0.422483
lRleftStd 0.157073
lRleftStdnorm 0.371785
lRleftMedian 0.390383
lRleftQuartdelta 0.226643
lRleftQuartdeltanorm 0.580566
lRleftKurt 2.4607
lRleftTrenddiff 0.0617837

Elel Segment 1

Elel Segment 2

Elel Segment 3

Elel Segment 4

Elel Segment 5

Elel Segment 6

Elel Segment 7

Elel Segment 8

Elel Segment 9

Elel Segment 10

Elel Segment 11

Elel Segment 12

Elel Segment 13

Elel Segment 14

FITTS Short Modified

meanTouchScore 0.631412
sumTouchScores 13.8911
meanMovementTime 0.880714
numTouches 22
undershootPercentage 4.54545
overshootPercentage 40.9091

fitts_short data not in signals file.

FITTS Long Modified

meanTouchScore 0.781871
sumTouchScores 7.81871
meanMovementTime 1.36167
numTouches 10
undershootPercentage 0
overshootPercentage 30

fitts_long data not in signals file.

ZigZag

numZigzags 5
timePerZigzagMean 20.92
timePerZigzagCoV 0.186074
timePerZigzagSlope -0.0340344
meanError 2.75706
tremorFreq 6.44531
tremorRelPower 25.9299
tremorGyroAmpMean 0.035652
tremorGyroAmpSlope -0.00257838
tremorGyroAmpCoV 0.283084
tremorCoordAmpMean 0.063842
tremorCoordAmpSlope -0.00245772
tremorCoordAmpCoV 0.295396
tremorAccAmpMean 0.0581664
tremorAccAmpSlope -0.00344968
tremorAccAmpCoV 0.316344
tremorPcRelVar 0.722707
tremorPcX -0.491173
tremorPcY -0.871062

ZigZag Segment 1

Duration 26.8 s, Accuracy Estimate 3.756 (lower is better)

ZigZag Segment 2

Duration 18.2 s, Accuracy Estimate 2.838 (lower is better)

ZigZag Segment 3

Duration 17.96 s, Accuracy Estimate 2.573 (lower is better)

ZigZag Segment 4

Duration 18.6 s, Accuracy Estimate 2.383 (lower is better)

ZigZag Segment 5

Duration 23.04 s, Accuracy Estimate 2.235 (lower is better)

ZigZag Offset

numZigzags 5
timePerZigzagMean 22.312
timePerZigzagCoV 0.0407315
timePerZigzagSlope 0.000358551
zigzagHeightMean 83.7108
zigzagHeightCoV 0.0876144
zigzagHeightSlope -0.0500798
meanError 0.0372895
tremorFreq 6.15234
tremorRelPower 30.0612
tremorGyroAmpMean 0.0378818
tremorGyroAmpSlope -0.00350118
tremorGyroAmpCoV 0.254889
tremorCoordAmpMean 0.061144
tremorCoordAmpSlope -0.00594162
tremorCoordAmpCoV 0.38061
tremorAccAmpMean 0.0846145
tremorAccAmpSlope -0.00140855
tremorAccAmpCoV 0.148272
tremorPcRelVar 0.729949
tremorPcX 0.371244
tremorPcY -0.928536

ZigZag Offset Segment 1

Duration 23.08 s, Accuracy Estimate 0.024 (lower is better)

ZigZag Offset Segment 2

Duration 20.8 s, Accuracy Estimate 0.037 (lower is better)

ZigZag Offset Segment 3

Duration 22.8 s, Accuracy Estimate 0.025 (lower is better)

ZigZag Offset Segment 4

Duration 22.72 s, Accuracy Estimate 0.026 (lower is better)

ZigZag Offset Segment 5

Duration 22.16 s, Accuracy Estimate 0.075 (lower is better)

Appendices

Misc

Currently a dumping ground for things that could be included or previous output style.

Note

Putting all the results out here but will not be in a final report.

HiSpec {‘HiSpec_class’: ‘NOT PD’, ‘HiSpec_score’: 0.76}
RanFor {‘RanFor_class’: ‘PD’, ‘RanFor_score’: 0.57}
BM_May22 {‘BM_May22_class’: ‘PD’, ‘BM_May22_score’: 0.26604992049676435}
BM_HC_Sep22 {‘BM_HC_Sep22_class’: ‘Patient’, ‘BM_HC_Sep22_score’: 0.9259413765174462}
BM_PD_Sep22 {‘BM_PD_Sep22_class’: ‘PD’, ‘BM_PD_Sep22_score’: 0.6953380440897785}